Interleukin-6 Contributes to Age-Related Alteration of Cytokine Production by Macrophages
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چکیده
منابع مشابه
Interleukin-6 Contributes to Age-Related Alteration of Cytokine Production by Macrophages
Here, we studied in vitro cytokine production by splenic macrophages obtained from young and aged BALB/c wild type (WT) and IL-6 knockout (IL-6 KO) mice. Relative to macrophages obtained from young WT mice given lipopolysaccharide (LPS), those from aged WT mice had decreased production of proinflammatory cytokines. In contrast, when compared to macrophages from young IL-6 KO mice, LPS stimulati...
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Antibiotics do not act alone but act in conjunction with the host defense system. In particular, it has been shown that some antibiotics can modify cytokine production. We compared the in vitro effects of three macrolides (roxithromycin, spiramycin, and erythromycin) actively concentrated by leukocytes on interleukin-1 alpha, (IL-1 alpha), IL-1 beta, IL-6, and tumor necrosis factor alpha produc...
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ژورنال
عنوان ژورنال: Mediators of Inflammation
سال: 2010
ISSN: 0962-9351,1466-1861
DOI: 10.1155/2010/475139